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2021 Project Proposal

Asymmetric Synthesis of Chiral Amines

Joseph Tanski (Chemistry)

Project Type - C - In-person-only: It will be cancelled if we are not allowed to have URSI students come to campus this summer.

The goal of this project is to investigate new reagents that will advance the state-of-the-art in the field of chiral amine synthesis. Specifically, the research will focus on compounds of transition metals with chiral ligands that will be investigated as reagents for imine (C=N) reductive hydrogenation to produce chiral hydrocarbon substituent on amines, and perhaps other similar organic transformations. We will prepare and characterize new imine substrates and reductive hydrogenation reagents, and examine the conversion to product amine, the stereoselectivity, and the mechanism of the transformation.

Prerequisites: Interested students must have completed Organic Chemistry 244/245 before the start of URSI, and experience with NMR would be helpful but is not required.

How should students express interest in this project? Before submitting their application, I invite interested students to write me an email with a short description of why they would like to conduct a synthetic chemistry project and how it fits into their overall academic pursuits as an undergraduate and beyond.

This is an 8-week project running from June 7 – July 31